Journal: Journal of Patient-Reported Outcomes
Article Title: Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease
doi: 10.1186/s41687-024-00805-w
Figure Lengend Snippet: Patient-level responder analysis ( A ) and group-level analysis ( B ) of PROMIS physical and fatigue domains and R-PAct outcomes in ERT-experienced patients. Patients with a change from baseline >0 in PROMIS Physical Function or R-PAct, or <0 for PROMIS Fatigue, were classed as ‘responders.’ *For the Fatigue endpoint, a negative change from the baseline value indicated a better health outcome. alg alglucosidase alfa, CFBL change from baseline, CI confidence interval, cipa cipaglucosidase alfa, ERT enzyme replacement therapy, LS least squares, mig miglustat, pbo placebo, PROMIS Patient-Reported Outcome Measurement Information System, R-Pact Rasch-built Pompe-specific Activity
Article Snippet: PROs evaluated included the Subject’s Global Impression of Change (SGIC), Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 20a, PROMIS Fatigue Short Form 8a, Rasch-built Pompe-specific Activity (R-PAct), and European Quality of Life-5 Dimensions 5 Response Levels (EQ-5D-5L).
Techniques: Activity Assay